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SUMMARY OF WORK (Use standard unreduced type. Do not exceed the Pletal Mg space provided.)
The LpC leukemia is a B cell leukemia of inbred strain 2 guinea pigs.
These cells have surface IgM and C3 receptors. Studies have shown that these
leukemia cells possess a strong tumor specific transplantation antigen (TSTA)
that can easily be Buy Pletal Online demonstrated by immunization protection tests in syngeneic
animals. Cilostazol Pletal A procedure employing KCl extraction of Buy Pletal the leukemic cell yields Pletal Tablets a
soluble extract that is also highly antigenic. The physical and chemical
properties of this soluble TSTA are now the subject of study. The findings to
date indicate that this Pletal 50 TSTA has several unusual properties; it has a M.W. of
10-15,000, (as determined by Sephadex chromatography and polyacryl amide gel
electrophoresis); it is resistant to boiling for 5 minutes as well as to
extremes of pH. Iso-electric focusing indicates that the immunogenic material
has a high isoelectric point, between 9-10. Treatment with trypsin,
neuraminidase and periodate destroys the activity. These characteristics
suggest that the TSTA is a basic glycoprotein of low molecular weight.
PHS 6040 (Rev. 1/83)
20-21
GPO 895-100
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00223-02 LI
PERIOD COVERED
nrtnhpr 1, lQft2 tn
Spptptnhpr ?n, iq«.?
TITLE OF PROJECT (80 charactert or lets. Title must fit on one line between the borders.)
Cellular Interactions in the Immune Pletal 100 Mg Response
PRINCIPAL INVESTIGATOR (List other professional personnel on subsequent pages.)
(Name, title, laboratory, and institute affiliation)
Ronald H. Schwartz, M.D., Ph.D.
COOPERATING UNITS (if any)
None
LAB/BRANCH
Laboratory of Immunology
NSTITUTE AND LOCATION
NIAID, NIH, Bethesda, Maryland 20205
TOTAL MANYEARS:
.3JI
PROFESSIONAL:
2.0
JL
CHECK APPROPRIATE BOX(ES)
□ (a) Human subjects
□ (a1) Minors
□ (a2) Interviews
□ (b) Hunnan tissues
W (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the tp ace provided.)
This Pletal 50 Mg project attempts to understand the biochemical basis for T
cell interactions with other cells in the immune system. During the past year
we have been able to analyze T cell activation by antigen and la molecules on
antigen-presenting cells in terms Pletal 50mg of a receptor occupancy model , originally
used to describe hormone activation of sensitive target cells. Using this
model we were able to design experiments to support the hypothesis that
variations Pletal Cilostazol in antigen dose response curves as a function of rest after
antigen-induced stimulation of T cell clones are related to variations in
antigen receptor number or affinity. This variation may play a critical role
in the phenomenon of T cell Purchase Pletal memory.
PHS 6040 (Rev. 1/83)
20-22
GPO 895-100
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00224-02 LI
PERIOD COVERED
October 1, 1982 to September 30, 1983
TITLE OF PROJECT (8 charactere or leee. Title muat fit on one line between the borders.)
Monoclonal antibodies as probes for T cell activation
PRINCIPAL INVESTIGATOR (List other professional personnel on subsequent pages.)
(Name, title, laboratory, and institute Pletal Cost affiliation)
Ethan M. Shevach, M.D. , Sr, Investigator, LI, NIAID
COOPERATING UNITS (if any)
LAB/BRANCH
.aboratory of Immunology
INSTITUTE AND LOCATION
^lAID, NIH, Bethesda, MD 20205
TOTAL MANYEARS:
4.5
PROFESSIONAL:
3
1.5
CHECK APPROPRIATE BOX(ES)
D Pletal Price (a) Human subjects
□ (a1) Minors
□ (a2) Interviews
□ (b) Human tissues
HE (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
We have developed a number of murine and rat monoclonal antibodies
to guinea pig and mouse T lymphocyte cell surface antigens which play
critical roles in the T cell activation process. One rat monoclonal
antibody (7D4) which was prepared against a murine IL-2 dependent cell
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